Work

Hepatitis C Virus Core Mutations Reduce the Sensitivity of a Fluorescence Enzyme Immunoassay

Year: 2000

Type: article

Abstract: Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.38.9.3450-3452.2000

Authors: Hajime Tokita, Gilbert R. Kaufmann, Mamoru Matsubayashi, Isao Okuda, Tsukasa Tanaka, Hideharu Harada, Motokazu Mukaide, Kazuo Suzuki, David A. Cooper

Institutions: UNSW Sydney, Tokyo National Hospital, SRL (Japan), St Vincent's Hospital Sydney

Language: English

Topic: Hepatitis C virus research

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2152918731

FWCI: 0.243

Cites: 15

Cited by: 17

Related to: 10