Work

Detection of human MCP-4/CCL13 isoforms by SELDI immunoaffinity capture

Year: 2006

Type: article

Abstract: Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. Recent evidence demonstrates that serum level of this protein strongly increases following high dose IL-2 immunotherapy. The physiological form of human MCP-4/CCL13 has yet to be purified. Therefore, the primary structure of the biologically relevant (mature) form has not been established. By using SELDI immunoaffinity capture technology we describe two mature isoforms both present in serum before and after high-dose IL-2 immunotherapy.

Source: Journal of Translational Medicine

DOI: 10.1186/1479-5876-4-5

Authors: Leonardo Rossi, Ramy Moharram, Brian M Martin, Richard L White, Monica C Panelli

Institutions: University of Pisa, National Institutes of Health, National Institute of Mental Health, Carolinas Medical Center, National Institutes of Health Clinical Center

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890