Work

Hierarchical Formation of Supramolecular Transient Networks in Water: A Modular Injectable Delivery System

Year: 2012

Type: article

Abstract: A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.

Source: Advanced Materials

DOI: 10.1002/adma.201104072

Authors: Patricia Y. W. Dankers, Thomas M. Hermans, Travis W. Baughman, Yuko Kamikawa, Roxanne E. Kieltyka, Maartje M. C. Bastings, Henk M. Janssen, Nico A. J. M. Sommerdijk, Antje Larsen, Marja J. A. van Luyn, Anton W. Bosman, Eliane R. Popa, George Fytas, E. W. Meijer

Institutions: University Medical Center Groningen, University of Groningen, Eindhoven University of Technology, SyMO-Chem (Netherlands), University of Crete, SupraPolix (Netherlands)

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Award: Functional Adaptive Supramolecular Systems for Medical Applications

OpenAlex ID: W2153173722

FWCI: 8.422

Cites: 51

Cited by: 299

Related to: 10