Work

Optimized Free Energies from Bidirectional Single-Molecule Force Spectroscopy

Year: 2008

Type: article

Abstract: An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy-valid for biasing potentials of arbitrary stiffness-are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies.

Source: Physical Review Letters

DOI: 10.1103/physrevlett.100.180602

Authors: David D. L. Minh, Artur B. Adib

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Force Microscopy Techniques and Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Award: Quantitative characterization of chemical reaction mechanisms