Work

The extracellular regulation of bone morphogenetic protein signaling

Year: 2009

Type: review

Abstract: In many cases, the level, positioning and timing of signaling through the bone morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in the extracellular space. Whereas many BMP-binding proteins inhibit signaling by sequestering BMPs from their receptors, other BMP-binding proteins cause remarkably context-specific gains or losses in signaling. Here, we review recent findings and hypotheses on the complex mechanisms that lead to these effects, with data from developing systems, biochemical analyses and mathematical modeling.

Source: Development

DOI: 10.1242/dev.031534

Authors: David Umulis, Michael B. O'Connor, Seth S. Blair

Institutions: Purdue University West Lafayette, University of Minnesota, Howard Hughes Medical Institute, University of Wisconsin–Madison

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, Purdue University, National Institutes of Health

OpenAlex ID: W2153336711

FWCI: 1.703

Cites: 159

Cited by: 204

Related to: 10