Year: 2007
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results. METHODS: We examined polymorphisms in the promoter region of the TGFB1 gene as well as the TGFBR1*6A microsatellite in the Nurses' Health Study cohort. RESULTS: No overall associations between the L10P polymorphism of TGFB1 or the TGFBR1 microsatellite were detected. However, we observed an inverse association between the -509 C/T polymorphism of TGFB1 (p-trend = 0.04), which was stronger and more significant among women with estrogen receptor positive breast cancer. CONCLUSION: Polymorphisms in the promoter region of TGFB1 are not likely to be associated with large increases in breast cancer risk overall among Caucasian women.
Source: BMC Cancer
Authors: David G Cox, Kathryn Penney, Qun Guo, Susan E Hankinson, David J Hunter
Institutions: Harvard University, Brigham and Women's Hospital
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,390
Awards: G1263749471, G151562090, Cohort Study of Genetic Susceptibility to Breast Cancer, Biochemical Markers in the nurses' Health Study Cohort, G2750880407, Dietary and Hormonal Determinants of Cancer in Women, G459566519, G4666650047, Biochemical Markers in the Nurses? Health Study Cohort, G9000040187, G9000190097, Program for Training in Cancer Epidemiology
OpenAlex ID: W2153351610