Work

The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis

Year: 2004

Type: review

Abstract: Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.

Source: Circulation Research

DOI: 10.1161/01.res.0000148632.35500.d9

Authors: Michael T. Crow, Kartik Mani, Young-Jae Nam, Richard N. Kitsis

Institutions: Albert Einstein College of Medicine, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences