In vivo mouse fluorescence imaging for folate-targeted delivery and release kinetics
Year: 2014
Type: article
Abstract: Many cancer cells over-express folate receptors, and this provides an opportunity for both folate-targeted fluorescence imaging and the development of targeted anti-cancer drugs. We present an optical imaging modality that allows for the monitoring and evaluation of drug delivery and release through disulfide bond reduction inside a tumor in vivo for the first time. A near-infrared folate-targeting fluorophore pair was synthesized and used to image a xenograft tumor grown from KB cells in a live mouse. The in vivo results are shown to be in agreement with previous in vitro studies, confirming the validity and feasibility of our method as an effective tool for preclinical studies in drug development.
Source: Biomedical Optics Express
DOI: 10.1364/boe.5.002662
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,913
Awards: Towards Deep Tissue Imaging of Fluorescence Resonance Energy Transfer Parameters, CIF: Small: Optical Diffusion Tomography, with Application to in Vivo Fluorescence Resonance Energy Transfer Imaging, CIF: Small: Fast In Vivo Optical Imaging in the Heavily and Weakly Scattering Regimes, Optical Imaging of Targeted Anti-Cancer Drug Delivery Kinetics
OpenAlex ID: W2153592609