Work

Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells

Year: 2005

Type: article

Abstract: Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic bone marrow transplantation, which is caused by donor T cells specific for host alloantigens. In a murine model, we found that donor T cells expressed a natural killer cell inhibitory receptor, CD94/NKG2A, during the course of aGVHD. Administration of an anti-NKG2A mAb markedly inhibited the expansion of donor T cells and ameliorated the aGVHD pathologies. These results suggested that the CD94/NKG2A inhibitory receptor expressed on host-reactive donor T cells can be a novel target for the amelioration of aGVHD.

Source: European Journal of Immunology

DOI: 10.1002/eji.200425933

Authors: Hiroki Kawamura, Hideo Yagita, Tetsuro Nisizawa, Nakako Izumi, Chikako Miyaji, Russell E. Vance, David H. Raulet, Ko Okumura, Toru Abo

Institutions: Juntendo University, Niigata University, University of California, Berkeley

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2153593709

FWCI: 0.714

Cites: 42

Cited by: 9

Related to: 10