Work

Lamin-binding Proteins

Year: 2010

Type: preprint

Abstract: A- and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in a plethora of stable and transient interactions, near the inner nuclear membrane and throughout the nucleus. Lamin-binding proteins serve an amazingly diverse range of functions. Numerous inner-membrane proteins help anchor lamin filaments to the nuclear envelope, serving as part of the nuclear "lamina" network that is essential for nuclear architecture and integrity. Certain lamin-binding proteins of the inner membrane bind partners in the outer membrane and mechanically link lamins to the cytoskeleton. Inside the nucleus, lamin-binding proteins appear to serve as the "adaptors" by which the lamina organizes chromatin, influences gene expression and epigenetic regulation, and modulates signaling pathways. Transient interactions of lamins with key components of the transcription and replication machinery may provide an additional level of regulation or support to these essential events.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a000554

Authors: K. L. Wilson, R. Foisner

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Max Perutz Labs, Medical University of Vienna

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: European Commission, Austrian Science Fund, National Institutes of Health, National Institute of General Medical Sciences

Awards: Training Program in Molecular, Cell, and Developmental Biology, Functional organization of the nucleus by LEM proteins, G6866001824