Work

Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment

Year: 2006

Type: article

Abstract: Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of "sterilization" in the development of new antituberculosis regimens.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00774-05

Authors: Geraint R. Davies, Richard Brindle, Saye H. Khoo, Leon J. Aarons

Institutions: University of Liverpool, Portsmouth Hospitals NHS Trust, University of Manchester

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Wellcome Trust