Work

Synthesis and biological evaluation of glutathione-like tripeptides against Trypanosoma cruzi

Year: 2003

Type: article

Abstract: Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design.We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups.All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi.

Source: ARKIVOC

DOI: 10.3998/ark.5550190.0004.a28

Authors: Esteban L. Ravaschino, Roberto Docampo, Juan B. Rodriguez

Institutions: Universidad de Buenos Aires, University of Illinois Urbana-Champaign

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: European Commission, Universidad de Buenos Aires