Year: 2005
Type: article
Abstract: New molecular entities identified by high-throughput screening methods are often poorly watersoluble and thus not easily absorbed in the gastrointestinal tract, due to limitations of dissolution and solubility.There are a variety of approaches to enhancing the drug dissolution and solubility.Particle size reduction is one of these approaches that have been demonstrated as an effective option.Reducing particle size and distribution range increases surface area and speeds up dissolution, thereby facilitating drug absorption.New technologies for obtaining particles in the nanoscale range are being developed [1].Even so, the ability to control the particles in nanoscale has only recently become part of drug research and development, and much excitement has centered on these technologies' applications for drug delivery [2][3][4].
Source: Microscopy and Microanalysis
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2153955010