Work

Science to Practice: Can Stem Cells Be Labeled Inside the Body Instead of Outside?

Year: 2013

Type: article

Abstract: Instead of conventional labeling ex vivo in cell culture, mesenchymal stem cells (MSCs) were labeled in vivo with intravenous injection of ferumoxytol (Feraheme; AMAG Pharmaceuticals, Lexington, Mass), a Food and Drug Administration (FDA)-approved intravenous iron supplement. After their isolation and processing from bone marrow, the same MSCs were injected in rats with an osteochondral defect, allowing MR monitoring of their engraftment for at least 4 weeks. This straightforward labeling approach, avoiding several regulatory issues, may accelerate clinical translation of magnetic resonance (MR) imaging for stem cell tracking.

Source: Radiology

DOI: 10.1148/radiol.13131753

Author: Jeff W. M. Bulte

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke