Work

Mutant and Wild-type Ras: Co-conspirators in Cancer

Year: 2013

Type: article

Abstract: Summary: Although the functional interplay between mutant and wild-type Ras in driving tumor initiation and growth has been described, a clear picture of the precise ramifications and mechanisms of this association remains elusive, sometimes with conflicting conclusions. A report in this issue of Cancer Discovery tackles this question, which may have important implications for therapeutic strategies to block mutant Ras for cancer treatment. Cancer Discov; 3(1); 24–6. ©2012 AACR. See related article by Young et al., p. 112

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-12-0521

Authors: Tikvah K. Hayes, Channing J. Der

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute