Work

Microfluidic Cell Sorter (μFCS) for On‐chip Capture and Analysis of Single Cells

Year: 2012

Type: article

Abstract: A low-cost and rapid microfluidic cell sorter (μFCS) for circulating tumor cell (CTC) detection, culture and analyses is developed. Based on size separation and molecular characterization, μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumor-bearing mice.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201200046

Authors: Jaehoon Chung, Huilin Shao, Thomas Reiner, David Issadore, Ralph Weissleder, Hakho Lee

Institutions: Massachusetts General Hospital, Center for Systems Biology, Harvard University

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering