Work

From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production

Year: 2014

Type: article

Abstract: As a young medical resident, I encountered a patient suffering from spontaneous coronary vasospasm and was puzzled by these dramatic alterations in vasomotion. This encounter piqued my interest in understanding the drivers of vascular reactivity. In a paper published in the JCI, my colleagues and I revealed a role for superoxide production in the vascular dysfunction associated with hypercholesterolemia. Subsequent work by our group and others has unveiled complex associations between ROS generation and vascular disease.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci70336

Author: David G. Harrison

Institution: Vanderbilt University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Vanderbilt University, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences