Work

Mechanical behaviour of primary human skeletal muscle cells and isolated non-myogenic cells within a 3D- construct

Year: 2005

Type: conference-abstract

Abstract: INTRODUCTION: An understanding of the mechanical and mechano-molecular responses that occur during the differentiation of primary human myoblasts in 3D-culture is critical for understanding growth and progress towards producing a tissue-engineered muscle construct1. In an effort to characterise the mechanical behaviour of myoblasts within a 3D construct, previous work by Cheema et al. (2003) utilised a cell line of immortalised skeletal myoblasts (c2c12 cells). The aim of this study was to determine the mechanical response of primary human skeletal muscle (PHSM) cells. Further, to isolate myoblasts from PHSM cells and establish the force generated by those cells.

Source: UCL Discovery (University College London)

Authors: Mariea A. Brady, R Brown, Mark P. Lewis, Vivek Mudera

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W2154140656

Cites: 1

Cited by: 2

Related to: 10