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Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Year: 2011

Type: article

Abstract: A-spiro-ing: The title reaction of α-isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201104216

Authors: Yiming Cao, Xianxing Jiang, Luping Liu, Fangfang Shen, Futing Zhang, Rui Wang

Institutions: Lanzhou University, State Key Laboratory of Applied Organic Chemistry, Hong Kong Polytechnic University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2154159907

FWCI: 17.2

Cites: 54

Cited by: 262

Related to: 10