Year: 2011
Type: article
Abstract: The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET. Keywords: 89Zr, zirconium-89, positron emission tomography, desferal, Immuno-PET, desferrioxamine, mAbs, monoclonal antibodies, cyclotron physics, yttrium target material, bifunctional chelate, desferrioxamine B
Source: Medicinal Chemistry
Institution: University of Wisconsin–Madison
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Cancer Institute
Awards: G1742644352, G2489417308
OpenAlex ID: W2154162767