Year: 2013
Type: article
Study design: Observational Study
Abstract: In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1781340182, AIDS Clinical Trials Group Network, G2291331489, G2344635089, G2349863769, G2650613164, G2737559749, G2800974659, G3206931443, UCLA Clinical and Translational Science Institute, G33819333, G349744246, G3611395682, G3944458741, G4161778824, G4553935269, G4632628815, G473273920, G4735891997, Mentoring Translational Research in HIV, Pooled Nucleic Acid Testing to Identify Antiretroviral Treatment Failure in India, G5211237770, G5466456334, G548982221, Improving Antiretroviral Management for HIV, G569886471, G5816822016, UCSD Department of Medicine HIV/AIDS Clinical Trials Unit, G5895897369, G5918387183, G5937357401, G6226294872, G650174051, G6695238679, Determinants of HIV Transmission, G764334320, Interdisciplinary Research Fellowship in NeuroAIDS, San Diego Center for AIDS Research (SD CFAR), HIV Neurobehavioral Research Center
OpenAlex ID: W2154174014