Year: 2015
Type: review
Abstract: Natural killer (NK) cells are innate lymphoid cells that are important for host defense against infection and mediate antitumor responses. Recent reports from several laboratories have identified that NK cells can remember a prior activation event and consequently respond more robustly when restimulated, a property termed innate NK cell memory. NK cell memory has now been identified following hapten exposure, viral infection, and combined cytokine preactivation with IL-12, IL-15, and IL-18. Many questions in the field remain regarding the cellular and molecular mechanisms regulating memory NK cells and their responses, as well as their formation and function in mice and humans. Here we review our current understanding of cytokine-induced memory-like (CIML) NK cells that are generated by combined preactivation with IL-12, IL-15, and IL-18. These cells exhibit enhanced NK cell effector functions weeks after the initial cytokine preactivation. Further, we highlight the preclinical rationale and ongoing therapeutic application of CIML NK cells for adoptive immunotherapy in patients with hematologic malignancies.
Source: Journal of Innate Immunity
DOI: 10.1159/000382019
Institution: Washington University in St. Louis
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Funders: Institute of Clinical and Translational Sciences, Gabrielle's Angel Foundation for Cancer Research, Alvin J. Siteman Cancer Center, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G1278655010, Mechanisms underlying cytokine-induced memory-like natural killer cell differentiation and maintenance., G3055874277, G3759946079, G5019318076, G611383016, Washington University Institute of Clinical and Translational Sciences, MICRORNA REGULATION OF NK CELL DEVELOPMENT AND FUNCTION, G7647900390, Washington University Institute of Clinical and Translational Sciences, G8669018785, Specialized Program of Research Excellence (SPORE) in Leukemia
OpenAlex ID: W2154179430