Work

Chemokines as Potential Markers in Pediatric Renal Diseases

Year: 2014

Type: review

Abstract: Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.

Source: Disease Markers

DOI: 10.1155/2014/278715

Authors: Ana Cristina Simões e Silva, André Barreto Pereira, Mauro Martins Teixeira, Antônio Lúcio Teixeira

Institutions: Universidade Federal de Minas Gerais, Instituto Nacional de Ciência e Tecnologia de Medicina Molecular, Grupo Santa Casa de Belo Horizonte

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,550