Associations of serum insulin-like growth factor-I and insulin-like growth factor-binding protein 3 levels with biomarker-calibrated protein, dairy product and milk intake in the Women's Health Initiative
Year: 2013
Type: article
Abstract: It is well established that protein-energy malnutrition decreases serum insulin-like growth factor (IGF)-I levels, and supplementation of 30 g of whey protein daily has been shown to increase serum IGF-I levels by 8 % after 2 years in a clinical trial. Cohort studies provide the opportunity to assess associations between dietary protein intake and IGF axis protein levels under more typical eating conditions. In the present study, we assessed the associations of circulating IGF axis protein levels (ELISA, Diagnostic Systems Laboratories) with total biomarker-calibrated protein intake, as well as with dairy product and milk intake, among postmenopausal women enrolled in the Women's Health Initiative (n 747). Analyses were carried out using multivariate linear regression models that adjusted for age, BMI, race/ethnicity, education, biomarker-calibrated energy intake, alcohol intake, smoking, physical activity and hormone therapy use. There was a positive association between milk intake and free IGF-I levels. A three-serving increase in milk intake per d (approximately 30 g of protein) was associated with an estimated average 18·6 % higher increase in free IGF-I levels (95 % CI 0·9, 39·3 %). However, total IGF-I and insulin-like growth factor-binding protein 3 (IGFBP-3) levels were not associated with milk consumption and nor were there associations between biomarker-calibrated protein intake, biomarker-calibrated energy intake, and free IGF-I, total IGF-I or IGFBP-3 levels. The findings of the present study carried out in postmenopausal women are consistent with clinical trial data suggesting a specific relationship between milk consumption and serum IGF-I levels, although in the present study this association was only statistically significant for free, but not total, IGF-I or IGFBP-3 levels.
Source: British Journal Of Nutrition
Institution: Albert Einstein College of Medicine
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: CLIN CTR FOR THE CLIN TRIAL & OBSERVATIONAL STUDY OF WHI, G1029522679, G109231058, G1107292973, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G1286168924, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G152626716, G156924709, Women's Health Initiative, G1593340546, G1610933967, G1617453120, G1646017446, Women's Health Initiative, Women's Health Initiative, G181468914, Women's Health Initiative, G206718646, G211028185, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G2182082016, G2253702613, G2286437695, G2295046671, G2417273319, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G2547046739, G257474614, Women's Health Initiative, G2768409618, STATISTICAL METHODS FOR MEDICINE STUDIES, G2852769941, G2880260212, G300426088, G3053443584, G306350359, G3290335435, Women's Health Initiative, G3337978133, Women's Health Initiative Memory Study (WHIMS), G3404453056, G3544793024, Women's Health Initiative, G3642616392, G3658685098, G3713777138, G3916577102, Women's Health Initiative, G4002295999, Women's Health Initiative, G401625215, Women's Health Initiative, G413560588, G4214622172, G4216744017, G4281851297, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, G4321061599, G4355687608, G445374210, G4454202622, Women's Health Initiative, G4560602636, Women's Health Initiative, G4713025228, G484043965, Women's Health Initiative, Women's Health Initiative, G4908813673, G4940723635, G5183277930, G5238945333, G5256332227, FOR ALL FIELD CENTER FOR WHI EXTENSION, G530368906, Women's Health Initiative, G532295152, G5415877130, Women's Health Initiative, G555506801, G5611709376, Women's Health Initiative, G5959015892, G5965015984, G603760282, Evidence for Establishing Optimum Protein Intake in Older Adults, G6424558485, G6464247198, G6522987136, G6730395537, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, G6893458194, Women's Health Initiative, G7066869570, G7071300326, G7223985928, G7272550893, Women's Health Initiative, G7323080267, G7422186829, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G7572166205, G7582705761, G7739768352, Women's Health Initiative, Nutrition and Physical Activity Assessment Study - Assessment of Dietary Supplements, CLINICAL CENTER FOR THE CLINICAL TRIAL & OBSERVATIONAL STUDY OF WHI, G8226798419, G857724489, G8606667874, G8780700017, G8898275213, G8913509553, G8934942062, G9000020404, G9000072420, G9000270366, G9000289100, G985928507, G999174792
OpenAlex ID: W2154337767