Work

Fluoroquinolone Resistance Is a Poor Surrogate Marker for Type II Topoisomerase Mutations in Clinical Isolates of Streptococcus pneumoniae

Year: 2001

Type: article

Abstract: The association between fluoroquinolone susceptibility and DNA mutations coding for amino acid substitutions in the quinolone resistance-determining region was assessed with 44 clinical isolates of Streptococcus pneumoniae. Twenty-three strains bore at least one amino acid substitution. Only seven strains with mutations were suggested by diminished susceptibility to ciprofloxacin (MIC, > or =2 microg/ml).

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.39.7.2719-2721.2001

Authors: John J. Millichap, Ekaterina Pestova, Farida Siddiqui, Gary A. Noskin, Lance R. Peterson

Institutions: Northwestern University, Northwestern Memorial Hospital

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green