Work

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade

Year: 2006

Type: article

Abstract: The programmed death (PD)-1-PD-1 ligand (PD-L) pathway, which is part of the B7-CD28 family, consists of the PD-1 receptor and its two ligands PD-L1 and PD-L2. Engagement of PD-1 by its ligands inhibits immune responses, and recent work has shown that PD-1 is highly expressed on exhausted T cells during chronic lymphocytic choriomeningitis virus (LCMV) infection in mice. Blockade of this pathway reinvigorates the exhausted T cells, allowing them to expand and produce effector cytokines, raising the issue of whether this pathway has been exploited by a variety of viruses during chronic infection. New studies now extend these observations to HIV infection and human disease.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20061800

Authors: Gordon J. Freeman, E. John Wherry, Rafi Ahmed, Arlene H. Sharpe

Institutions: The Wistar Institute, Brigham and Women's Hospital, Harvard University, Emory University, Dana-Farber Cancer Institute

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases