Work

Synthesis and Structure–Activity Relationships of Lansine Analogues as Antileishmanial Agents

Year: 2012

Type: article

Abstract: Clear and rational thinking: A series of rationally designed, lansine-derived carbazoles was synthesized and evaluated for activity against promastigotes and amastigotes of Leishmania donovani, the causative agent of leishmaniasis. Some structural modifications gave rise to compounds with enhanced activity and selectivity over lansine, allowing structure-activity relationships to be elucidated and providing a foundation for the further development of this pharmacophore.

Source: ChemMedChem

DOI: 10.1002/cmdc.201200346

Authors: Marco Pieroni, Sisay Girmay, Dianqing Sun, Rajnish Sahu, Babu L. Tekwani, Ghee T. Tan

Institutions: University of Parma, University of Hawaii at Hilo, University of Mississippi

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources, Medical Research and Materiel Command