Work

Retinal Pigment Epithelial Cells Release inhibitors of Neovascularization

Year: 1987

Type: article

Abstract: Human retinal pigment epithelial (RPE) cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells and human retinal microvessel endothelial cells in vitro. Neither astrocytes nor fibroblasts under identical test conditions released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human RPE cells released higher levels of inhibitor than confluent cultures.

Source: Ophthalmology

DOI: 10.1016/s0161-6420(87)33529-8

Authors: Bert M. Glaser, Peter A. Campochiaro, John L. Davis, Janice A. Jerdan

Institutions: Johns Hopkins University, University of Virginia

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,990