Work

Oral Immunization withAcanthamoeba castellaniiMannose-Binding Protein Ameliorates Amoebic Keratitis

Year: 2006

Type: article

Abstract: Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In the present study, we demonstrate that oral immunization with recombinant MBP ameliorates AK in a hamster animal model and that this protection is associated with the presence of elevated levels of anti-MBP immunoglobulin A in the tear fluid of the immunized animals.

Source: Infection and Immunity

DOI: 10.1128/iai.00828-06

Authors: M. Garate, H. Alizadeh, S. Neelam, J. Y. Niederkorn, N. Panjwani

Institutions: The University of Texas Southwestern Medical Center, Tufts University

Language: English

Topic: Legionella and Acanthamoeba research

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute