Work

Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Year: 2008

Type: article

Study design: Observational Study

Abstract: We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (18F-FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

Source: Medical Physics

DOI: 10.1118/1.2826560

Authors: Soren D. Konecky, Regine Choe, Alper Corlu, Kijoon Lee, Rony Wiener, Shyam M. Srinivas, Janet R. Saffer, Richard Freifelder, Joel S. Karp, Nassim Hajjioui, Fred Azar, Arjun G. Yodh

Institutions: University of Pennsylvania, Siemens (United States)

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: Diffuse Optics for Acute Stroke Management, G1530775073, G1858056967, Multi-Spectral Parallel-Plate Diffuse Optical Breast Tomography, G309327476, G376811913, Breast Cancer Multi-dimensional Diffuse Optical Imaging, DET/COMPUTATION FOR DIFFUSE OPTICAL TOMOGRAPHY OF BREAST, G5557126095, G7394545016, G974849508

OpenAlex ID: W2154698701

FWCI: 5.098

Cites: 69

Cited by: 35

Related to: 10