Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli
Year: 1991
Type: article
Abstract: Thirteen spontaneous quinolone-resistant gyrB mutants of Escherichia coli KL16, including two that were examined previously, were divided into two types according to their quinolone resistance patterns. Type 1 mutants were resistant to all the quinolones tested, while type 2 mutants were resistant to acidic quinolones and were hypersusceptible to amphoteric quinolones. Nucleotide sequence analysis disclosed that all nine type 1 mutants had a point mutation from aspartic acid to asparagine at amino acid 426 and that all four type 2 mutants had a point mutation from lysine to glutamic acid at amino acid 447.
Authors: H Yoshida, M Bogaki, M Nakamura, L M Yamanaka, S Nakamura
Institution: Sumitomo Dainippon Pharma (Japan)
Language: English
Subfield: Microbiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2154806021