Work

Palatogenesis and cutaneous repair: A two‐headed coin

Year: 2014

Type: review

Abstract: BACKGROUND: The reparative mechanism that operates following post-natal cutaneous injury is a fundamental survival function that requires a well-orchestrated series of molecular and cellular events. At the end, the body will have closed the hole using processes like cellular proliferation, migration, differentiation and fusion. RESULTS: These processes are similar to those occurring during embryogenesis and tissue morphogenesis. Palatogenesis, the formation of the palate from two independent palatal shelves growing towards each other and fusing, intuitively, shares many similarities with the closure of a cutaneous wound from the two migrating epithelial fronts. CONCLUSIONS: In this review, we summarize the current information on cutaneous development, wound healing, palatogenesis and orofacial clefting and propose that orofacial clefting and wound healing are conserved processes that share common pathways and gene regulatory networks.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.24224

Authors: Leah C. Biggs, Steven L. Goudy, Martine Dunnwald

Institutions: University of Iowa, Vanderbilt University, Vanderbilt University Medical Center

Language: English

Topic: Cleft Lip and Palate Research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases