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Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

Year: 2008
Type: article
Abstract: Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).
DOI: 10.1002/anie.200803526
Authors: Ying‐Ying Wang, Samuel K. Lai, Jung Soo Suk, Amanda Pace, Richard Cone, Justin Hanes
Language: English
Open Access status: bronze
Funders: National Science Foundation, Croucher Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering
Awards: Polymer nanoparticles that cross mucus, G198680246, Duet cervical barrier device for maximizing protective efficacy of microbicides, G4942534574, G6948146, G9000067843
OpenAlex ID: W2154855352
FWCI: 14.54
Cites: 35
Cited by: 597
Related to: 10