Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field
Year: 2012
Type: article
Abstract: Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines, hypereosinophilia may develop and may lead to organ damage. In other patients, persistent eosinophilia is accompanied by typical clinical findings, but the causative role and impact of eosinophilia remain uncertain. For patients with eosinophil-mediated organ pathology, early therapeutic intervention with agents reducing eosinophil counts can be effective in limiting or preventing irreversible organ damage. Therefore, it is important to approach eosinophil disorders and related syndromes early by using established criteria, to perform all appropriate staging investigations, and to search for molecular targets of therapy. In this article, we review current concepts in the pathogenesis and evolution of eosinophilia and eosinophil-related organ damage in neoplastic and non-neoplastic conditions. In addition, we discuss classifications of eosinophil disorders and related syndromes as well as diagnostic algorithms and standard treatment for various eosinophil-related disorders.
Source: Expert Review of Hematology
DOI: 10.1586/ehm.11.81
Authors: Peter Valent, Gerald J Gleich, Andreas Reiter, Florence Roufosse, Peter F Weller, Andrzej Hellmann, Georgia Metzgeroth, Kristin M Leiferman, Michel Arock, Karl Sotlar, Joseph H Butterfield, Sabine Cerny-Reiterer, Matthias Mayerhofer, Peter Vandenberghe, Torsten Haferlach, Bruce S Bochner, Jason Gotlib, Hans-Peter Horny, Hans-Uwe Simon, Amy D Klion
Institutions: Medical University of Vienna, University of Utah, University Medical Centre Mannheim, Université Libre de Bruxelles, Erasmus Hospital, Beth Israel Deaconess Medical Center, Harvard University, Gdańsk Medical University, École Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Laboratoire de Biologie et Pharmacologie Appliquée, Pathologisches Institut, Ludwig-Maximilians-Universität München, Mayo Clinic, Ludwig Boltzmann Institute for Hematology and Oncology, KU Leuven, Munich Leukemia Laboratory (Germany), Johns Hopkins University, Johns Hopkins Medicine, Stanford Medicine, Stanford University, University of Bern, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G2614607763, G6014266152
OpenAlex ID: W2155001002