Work

Tetrazine Phototriggers: Probes for Peptide Dynamics

Year: 2010

Type: article

Abstract: Surrender your secrets, peptides! Of several 3,6-disubstituted tetrazines examined as phototriggers for the investigation of peptide dynamics, the most useful candidates were disulfenyl tetrazines. The thiocyanate fragments resulting from photolysis (see scheme) were detected by ultrafast infrared spectroscopy. Chromophore insertion into oxytocin and photofragmentation to trigger peptide relaxation were both demonstrated.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201000500

Authors: Matthew J. Tucker, Joel R. Courter, Jianxin Chen, Onur Atasoylu, Amos B. Smith, Robin M. Hochstrasser

Institution: University of Pennsylvania

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Center for Research Resources

Awards: G255748793, ULTRAFAST OPTICAL PROCESSES LABORATORY, G5482926439