Work

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

Year: 2014

Type: article

Abstract: A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.

Source: Chemical Communications

DOI: 10.1039/c4cc02346c

Authors: Bogdan Draghici, Daniela Vullo, Suleyman Akocak, Ellen A. Walker, Claudiu T. Supuran, Marc A. Ilies

Institutions: Temple University, University of Florence

Language: English

Topic: Enzyme function and inhibition

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2155165239