Work

Cross-Recognition of N -Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8 + T Cells

Year: 2005

Type: article

Abstract: H2-M3-restricted CD8+ T cells can exhibit cross-reactivity to different bacterially derived N-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

Source: Infection and Immunity

DOI: 10.1128/iai.73.7.4423-4426.2005

Authors: Alexander Ploss, An Tran, Ewa Menet, Ingrid Leiner, Eric G. Pamer

Institutions: Memorial Sloan Kettering Cancer Center, Cornell University, Weill Cornell Medicine

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cancer Research Institute, National Institutes of Health, National Institute of Allergy and Infectious Diseases