Ovarian development, function, and granulosa cell tumorigenesis : Role of GATA Transcription Factors and Anti-Müllerian Hormone
Year: 2005
Type: dissertation
Abstract: 6 LIST OF ORIGINAL PUBLICATIONS 8 ABBREVIATIONS 9 INTRODUCTION 10 REVIEW OF THE LITERATURE 12 1 GATA family of transcription factors 12 1.1 Structure and mode of action 12 1.2 Tissue-specific expression and function during development 13 2 Embryonic development of the female reproductive tract 15 2.1 Bipotential gonad and sex ducts 15 2.2 Regulation of sexual differentiation 15 Anti-Mullerian hormone (AMH) 16 Steroidogenic factor 1 and GATA-4 17 2.3 Passive versus active signaling in the fetal ovary 17 Wnt4 and DAX-1 18 2.4 Human reproductive tract development disorders 18 3 Ovarian function 21 3.1 Endocrine regulation of folliculogenesis 21 FSH and LH 21 Intracellular gonadotropin pathway 22 3.2 Paracrine interplay between oocytes and granulosa and theca cells 23 Oocyte-derived GDF9 and BMP15 23 Inhibin 24 AMH 24 3.3 Granulosa cell proliferation 25 3.4 Apoptosis in the ovary 26 4 Ovarian granulosa cell tumors 27 4.1 Incidence and clinical characteristics 27 4.2 Diagnosis, treatment, and prognosis 28 4.3 Pathologic and cytogenetic characteristics 28 4.4 Molecular pathogenesis: dysregulation of normal granulosa cell function? 29 FSH and cyclin D2 29 MAPK, TGF-β, and Wnt signaling 29 Inhibin and AMH 30 AIMS OF THE STUDY 31
Source: Työväentutkimus Vuosikirja
Author: Mikko Anttonen
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2155328421