Work

Prognostic Value of IL-7 and SCF Levels on Thymic Reconstitution and Clinical Outcomes after Double Umbilical Cord Transplantation in Adults

Year: 2015

Type: article

Abstract: Umbilical cord blood transplantation (UCBT) is characterized by delayed immune reconstitution even with the use of double unit UCBT (dUCBT). Previously we reported that reconstitution of thymopoiesis, as determined by assessment of T-cell receptor excision circles (TRECs), plays a critical role in the clearance of CMV viremia and is associated with improved overall survival in dUCBT recipients. We also determined that recovery of specific T-cell subsets after dUCBT correlates with serum levels of Interleukin 7 (IL-7) and Stem Cell Factor (SCF).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.245