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Mixed-Strain Mycobacterium tuberculosis Infections and the Implications for Tuberculosis Treatment and Control

Year: 2012
Type: review
Abstract: Numerous studies have reported that individuals can simultaneously harbor multiple distinct strains of Mycobacterium tuberculosis. To date, there has been limited discussion of the consequences for the individual or the epidemiological importance of mixed infections. Here, we review studies that documented mixed infections, highlight challenges associated with the detection of mixed infections, and discuss possible implications of mixed infections for the diagnosis and treatment of patients and for the community impact of tuberculosis control strategies. We conclude by highlighting questions that should be resolved in order to improve our understanding of the importance of mixed-strain M. tuberculosis infections.
DOI: 10.1128/cmr.00021-12
Authors: Ted Cohen, Paul D. van Helden, Douglas Wilson, Caroline Colijn, Megan M. McLaughlin, Ibrahim Abubakar, Robin M. Warren
Institutions: Brigham and Women's Hospital, Harvard University, Stellenbosch University, Edendale Hospital, University of KwaZulu-Natal, Imperial College London, University of East Anglia
Language: English
Field: Medicine
Open Access status: bronze
OpenAlex ID: W2155465294
FWCI: 1.461
Cites: 114
Cited by: 188
Related to: 10