Work

Integrin activation takes shape

Year: 2002

Type: review

Abstract: Integrins are cell surface adhesion receptors that are essential for the development and function of multicellular animals. Here we summarize recent findings on the regulation of integrin affinity for ligand (activation), one mechanism by which cells modulate integrin function. The focus is on the structural basis of integrin activation, the role of the cytoplasmic domain in integrin affinity regulation, and potential mechanisms by which activation signals are propagated from integrin cytoplasmic domains to the extracellular ligand-binding domain.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.200206011

Authors: R.C. Liddington, M.H. Ginsberg

Institutions: Sanford Burnham Prebys Medical Discovery Institute, Scripps Research Institute

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: green

OpenAlex ID: W2155510991

FWCI: 3.429

Cites: 51

Cited by: 301

Related to: 10