Work

A twisted tRNA intermediate sets the threshold for decoding: FIGURE 1.

Year: 2003

Type: article

Abstract: Putting together consistent cryo-EM structure, transient kinetic and mutant tRNA suppressor data, it appears that a deformed or waggling aminoacyl-tRNA is the critical transitional structure examined by the ribosome during decoding at the A site. The unusual conformation may be required for effective proofreading of the codon-anticodon complex.

Source: RNA

DOI: 10.1261/rna.2184703

Authors: MICHAEL YARUS, MIKEL VALLE, JOACHIM FRANK

Institutions: University of Colorado Boulder, Howard Hughes Medical Institute, State University of New York, University at Albany, State University of New York

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2155668679

FWCI: 1.034

Cites: 6

Cited by: 39

Related to: 10