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Combined Proline–Surfactant Organocatalyst for the Highly Diastereo‐ and Enantioselective Aqueous Direct Cross‐Aldol Reaction of Aldehydes

Year: 2006

Type: article

Abstract: Why not combine the two? The asymmetric direct aldol reaction of two different aldehydes was catalyzed by a combined proline–surfactant organic catalyst in the presence of water. A stable emulsion was formed in the reaction mixture, and the aldols were obtained with excellent diastereo- and enantioselectivities (see scheme).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200601156

Authors: Yujiro Hayashi, Seiji Aratake, Tsubasa Okano, Junichi Takahashi, Tatsunobu Sumiya, Mitsuru Shoji

Institution: Tokyo University of Science

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Ministry of Education, Culture, Sports, Science and Technology, Toray Science Foundation

OpenAlex ID: W2155678338

FWCI: 20.68

Cites: 26

Cited by: 300

Related to: 10