Work

The M2 Proton Channels of Influenza A and B Viruses

Year: 2005

Type: review

Abstract: Influenza A virus and influenza B virus are two different enveloped, negative stranded RNA viruses that cause epidemic infections. The virion (virus particle) of each virus contains a small integral membrane protein (A/M2 and BM2, respectively) that functions as a proton channel and is essential to viral replication. These proton channels are of interest because they are among the smallest bona fide ion channel proteins (with the properties of ion selectivity and activation), and they succeed in accomplishing the same function with only a meager similarity in primary amino acid sequence.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r500020200

Authors: Lawrence H. Pinto, Robert A. Lamb

Institutions: Northwestern University, Howard Hughes Medical Institute

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Institute of Allergy and Infectious Diseases