Work

CoCEST: cobalt(ii) amide-appended paraCEST MRI contrast agents

Year: 2013

Type: article

Abstract: The first examples of air-stable Co(II) paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

Source: Chemical Communications

DOI: 10.1039/c3cc45000g

Authors: Sarina J. Dorazio, Abiola O. Olatunde, Joseph A. Spernyak, Janet R. Morrow

Institutions: University at Buffalo, State University of New York, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G881394232, Roswell Park Cancer Center Support Grant, Iron paraCEST MRI Contrast Agents for Monitoring Tumor Acidosis