Work

Replication of Minute Virus of Mice in Murine Cells Is Facilitated by Virally Induced Depletion of p21

Year: 2012

Type: article

Abstract: The DNA damage response to infection with minute virus of mice (MVM) leads to activated p53; however, p21 levels are reduced via a proteasome-mediated mechanism. This loss was sustained, as virus replicated in infected cells held at the G(2)/M border. Addition of the cyclin-dependent kinase (CDK) inhibitor roscovitine after S-phase entry reduced MVM replication, suggesting that CDK activity was critical for continued viral replication and virus-induced reduction of p21 may thus be necessary to prevent inhibition of CDK.

Source: Journal of Virology

DOI: 10.1128/jvi.00820-12

Authors: Richard O. Adeyemi, David J. Pintel

Institution: University of Missouri

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases