Multiscale modelling of insulin secretion during an intravenous glucose tolerance test
Year: 2013
Type: article
Abstract: Dysfunctional insulin secretion from pancreatic β-cells plays a major role in the development of diabetes. The intravenous glucose tolerance test (IVGTT) is a widely used clinical test to assess β-cell function. The analysis of IVGTT data is conveniently performed using mathematical models, which need to be fairly simple to enable parameter identifiability (minimal models), but should at the same time have sound biological foundation at the cellular level. Using mathematical analysis and model reduction, we show here that our recent mathematical model of insulin secretory granule dynamics in β-cells provides mechanistic underpinning for our minimal model of pancreatic insulin secretion during an IVGTT.
Source: Interface Focus
Authors: Morten Gram Pedersen, Claudio Cobelli
Institution: University of Padua
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2156157884