Work

The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure

Year: 2006

Type: review

Abstract: Histone post-translational modifications occur, not only in the N-terminal tail domains, but also in the core domains. While modifications in the N-terminal tail function largely through the regulation of the binding of non-histone proteins to chromatin, based on their location in the nucleosome, core domain modifications may also function through distinct mechanisms involving structural alterations to the nucleosome. This article reviews the recent developments in regards to these novel histone modifications and discusses their important role in the regulation of chromatin structure.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gkl338

Authors: E. L. Mersfelder, M. R. Parthun

Institution: The Ohio State University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

Funders: National Institutes of Health, National Institute of General Medical Sciences