Work

Receiver operator characteristics of the Sysmex HPC measurement used to initiate apheresis of blood hematopoietic progenitor cells

Year: 2006

Type: article

Abstract: Background: Hematopoietic progenitor cells (HPC) can be mobilized into the peripheral blood by the administration of G-CSF and/or GM-CSF and collected by apheresis for patients who are candidates for high dose chemotherapy and autologous stem cell transplantation. The initiation of apheresis is commonly based upon the number of CD34+ cells/μL in the blood, using a flow cytometric assay that typically requires 2 hours for sample preparation, acquisition, and reporting results. The availability of a new technology for rapidly measuring the content of hematopoietic progenitor cells in blood samples based upon size and impedance (Sysmex™) prompted an evaluation of how this method compares to the CD34+ flow cytometric assay.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.034

Authors: E.S. Hamilton, C.R. Flowers, M.L. Vaughn, M. Minerley, E.K. Waller

Institutions: Emory Healthcare, Emory University, Winship Cancer Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650