Work

Ketamine – More mechanisms of action than just NMDA blockade

Year: 2014

Type: article

Abstract: Ketamine has been in clinical use for over half a century, yet its precise mechanisms of action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated by blockade of NMDA and HCN1 receptors, but cholinergic, aminergic, and opioid systems appear to play both a positive and negative modulatory role in both sedation and analgesia. Ketamine's effects in chronic pain, and as an antidepressant, far outlast the actual drug levels, and are probably mediated by a secondary increase in structural synaptic connectivity that is mediated by a neuronal response to the ketamine-induced hyper-glutamatergic state.

Source: Trends in Anaesthesia and Critical Care

DOI: 10.1016/j.tacc.2014.03.002

Authors: Jamie Sleigh, Martyn Harvey, Logan Voss, Bill Denny

Institutions: University of Auckland, Waikato Hospital

Language: English

Topic: Anesthesia and Sedative Agents

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,660